Samprikta (Sam) Manna
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Project Title: Axis of Placental Aging in Adverse Pregnancy Outcomes: Telomerese and Mitochondria
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Samprikta holds a Bachelors in Dental Surgery from Rani Durgavati University, Madhya Pradesh, India. She worked as a full-time dentist for about 2 years before opting for post-graduation in Ireland. Sam relocated and became a part of University College Cork in September 2017 as a Masters in Molecular Cell Biology and Bioinnovation student. She did her research project in APC Microbiome Institute, UCC, Ireland, where she looked at the changes in physiology, gene expression and mitochondrial functions in colon cancer cells when treated with bile acids and lipids.
In August 2018, Sam was accepted as an early-stage researcher within the iPlacenta consortium and she was enrolled for Ph.D. Medicine (Obstetrics and Gynaecology) at University College Cork. Sam’s current research is focused on understanding the process by which cellular and mitochondrial senescence can play a key role in premature ageing of the placenta in adverse pregnancy outcomes such as pre-eclampsia and intrauterine growth restriction. For her project, Sam recruits both healthy pregnant women and pregnancies complicated by preeclampsia and intrauterine growth restriction from Cork University Maternity Hospital. She collects blood, urine, placenta, and cord blood from the mothers. All her samples are stored in INFANT Biobank. The main aims of Sam’s project are: A) To elucidate the molecular signalling networks mediating premature placental aging in adverse pregnancy outcomes including pre-eclampsia, intrauterine growth restriction at a cellular (trophoblast) level, whole tissue placental level, and plasma mediated level. B) To identify senolytic agents and advance the development of therapeutic strategies targeting these pathways.
In August 2018, Sam was accepted as an early-stage researcher within the iPlacenta consortium and she was enrolled for Ph.D. Medicine (Obstetrics and Gynaecology) at University College Cork. Sam’s current research is focused on understanding the process by which cellular and mitochondrial senescence can play a key role in premature ageing of the placenta in adverse pregnancy outcomes such as pre-eclampsia and intrauterine growth restriction. For her project, Sam recruits both healthy pregnant women and pregnancies complicated by preeclampsia and intrauterine growth restriction from Cork University Maternity Hospital. She collects blood, urine, placenta, and cord blood from the mothers. All her samples are stored in INFANT Biobank. The main aims of Sam’s project are: A) To elucidate the molecular signalling networks mediating premature placental aging in adverse pregnancy outcomes including pre-eclampsia, intrauterine growth restriction at a cellular (trophoblast) level, whole tissue placental level, and plasma mediated level. B) To identify senolytic agents and advance the development of therapeutic strategies targeting these pathways.
Nationality: Indian
Institution: University College Cork, Ireland
Supervisors:
Dr Fergus McCarthy, Cork University Maternity Hospital
Dr Cathal McCarthy, University College Cork
Dr Fergus McCarthy, Cork University Maternity Hospital
Dr Cathal McCarthy, University College Cork
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Email: [email protected]
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ResearchGate: Samprikta Manna
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