Project Description University College Cork and the Irish Centre for Fetal and Translational Research are looking for an Early Stage Researcher (ESR) with a focus on developing a placental ageing platform to investigate the role of cellular senescence in adverse pregnancy complications including preeclampsia and intrauterine growth restriction.
About University College Cork and INFANT University College Cork (UCC) is the current Sunday Times University of the Year and additionally, is now placed 52nd out of 750 leading universities based on research papers published in top academic journals. UCC has been recently awarded the European Commission’s award of HR Excellence in Research. This award recognises the progress, which has been made in support of researchers, including the implementation of the University Research Employment and Career Management Structure and an on-going commitment to supporting the principles of the European Charter and Code for Researchers. UCC is committed to excellence in teaching and learning, providing a supportive and caring environment for all researchers. UCC provides a wide range of support mechanisms for the integration of researchers, including a well-developed infrastructure that provides training in a wide range of complementary skills. The University also supports a diverse range of training courses including STEPS (Scientific Training for Enhanced Postgraduate Study) among many others that develop transferable skills in addition to specific research skills training.
INFANT has a highly evolved research platform with a core emphasis on delivering innovations in perinatal healthcare. The centre is accommodated within the CUMH, Europe’s second busiest maternity unit and is the first purpose-built, integrated research and clinical centre of Perinatal Research in Ireland. INFANT is home to the Screening for Pregnancy Endpoints (SCOPE) Study, a prospective longitudinal case cohort of pregnancy outcome, which contributes to the world’s largest global pregnancy biobank. The ESR will be based in the INFANT Centre and will be supported by the expertise of INFANT multidisciplinary teams, consisting of clinicians, scientists, biostatisticians, regulatory and financial personnel.
The project also involves a collaboration with Professor Louise Kenny, Pro-Vice Chancellor, University of Liverpool and it is envisaged the PhD candidate will spend time in Professor Kenny’s research group in Liverpool.
Project description: The project is part of iPlacenta (www.iplacenta.eu), a new European Union’s Horizon 2020 research and innovation programme ITN under the Marie Skłodowska-Curie, to model the placenta for early detection of PE/IUGR, and to train the next generation of Translational Scientists for Maternal and Foetal Health.
The focus of the project is to Investigate the pathophysiological role of premature placental aging and senescence in adverse pregnancy outcomes including pre-eclampsia, intrauterine growth restriction, gestational diabetes and stillbirth. Secondly to identify metabolomic biomarkers of placental aging and thereby advance the development of therapeutic strategies targeting these pathways. There will also opportunities to apply your research and collaborate with fellow trainees in the consortium on cross-disciplinary projects.
Your profile: - Interests in developing and translating technology to answer medical questions and solve healthcare problems in women health - Strong understanding in Cell and Molecular Biology - Good knowledge of (3D) cell culture and laboratory equipment such as microscopes and plate readers; - Able to communicate with scientists, engineers and clinicians of different disciplines; - Have a motivated, flexible and positive work attitude; - Proficiency in English language.
Eligibility: To this position applies a mobility rule. The respective candidate must not have worked for more than 12 months in the Republic of Ireland within the last three years. Furthermore, the candidate needs to be in his/her first four years of his/her research career. The four years are counted from the date a degree was obtained which formally entitles to embark on a doctorate in the country either in the country in which the degree was obtained or in the country in which the research training is provided.
Starting date: 1st Sept 2018 or soon thereafter ideally before Oct 2018 Duration: 36 months Salary: Competitive remuneration: Monthly Gross salary before any deductions (Living Allowance, €3110/month; mobility allowance, €600/month, family allowance if applicable, €500/month). Exact salary to be paid in local currency and calculated per country after correction factor in accordance to the Marie Curie-ITN rules Deadline for application: Midnight (GMT) 18th June 2018