Dr. Colin E. Murdoch
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Senior Lecturer &
Project Coordinator of iPLACENTA Horizon2020 ITN Division of Molecular & Clinical Medicine, University of Dundee +44(0)1382 383526 |
Research Interests I am interested in how redox signaling effects cardiovascular pathophysiology. In particular my research has concentrated on redox signaling in the endothelial and inflammatory cell and the implication on cardiovascular function in vivo. I have focused on several targets in pre-eclampsia using clinical samples, murine models and in vitro studies. One aspect is to investigate during pre-eclampsia whether signaling is affected by the S- glutathionylation, a post-translation modification which occurs during oxidative stress.
My previous research in Boston identified how angiogenesis is regulated by S- glutathionylation. At Kings College London I utilised cell specific genetically modified mice to decipher the role of different NADPH oxidase isoforms, Nox2 and Nox4 in the endothelium on left ventricular hypertrophy and hypertension. I successfully modelled a human disease in a mouse, measured cardiovascular parameters and subsequently conducted biochemical and molecular assays in order to identify novel molecular mechanisms.
My previous research in Boston identified how angiogenesis is regulated by S- glutathionylation. At Kings College London I utilised cell specific genetically modified mice to decipher the role of different NADPH oxidase isoforms, Nox2 and Nox4 in the endothelium on left ventricular hypertrophy and hypertension. I successfully modelled a human disease in a mouse, measured cardiovascular parameters and subsequently conducted biochemical and molecular assays in order to identify novel molecular mechanisms.
Biography
Dr Murdoch joined the faculty at School of Medicine, University of Dundee in March 2018. His research focuses on the pathophysiological role of redox signalling in cardiovascular disease including preeclampsia and peripheral artery disease.
Dr Colin Murdoch obtained his doctorate under the supervision of the Prof Ajay Shah, through the British Heart Foundation 4-year Ph.D program at the BHF Cardiovascular Centre of Excellence, King’s College London. He investigated the “Influence of endothelial NADPH oxidase on cardiac fibrosis and remodelling in the hypertensive heart.”, utilising murine cardiovascular techniques such as pressure-volume loops, echocardiography and telemetry.
Dr Murdoch conducted post-doctoral training with Richard Cohen and Reiko Matsui at the Whitaker Cardiovascular Institute, Boston University investigating the role of redox signalling in neovascularisation in type-2 diabetes. He moved back to the UK and was awarded a highly competitive Marie Skłodowska-Curie International Incoming Fellowship to transfer in vivo cardiovascular phenotyping techniques to Aston Medical School working in Prof Asif Ahmed’s laboratory.
Previously he worked as a functional pharmacologist for 5-years with Asterand Bioscience after gaining his honours degree in Pharmacology with Industrial Experience at University of Edinburgh.
Dr Murdoch joined the faculty at School of Medicine, University of Dundee in March 2018. His research focuses on the pathophysiological role of redox signalling in cardiovascular disease including preeclampsia and peripheral artery disease.
Dr Colin Murdoch obtained his doctorate under the supervision of the Prof Ajay Shah, through the British Heart Foundation 4-year Ph.D program at the BHF Cardiovascular Centre of Excellence, King’s College London. He investigated the “Influence of endothelial NADPH oxidase on cardiac fibrosis and remodelling in the hypertensive heart.”, utilising murine cardiovascular techniques such as pressure-volume loops, echocardiography and telemetry.
Dr Murdoch conducted post-doctoral training with Richard Cohen and Reiko Matsui at the Whitaker Cardiovascular Institute, Boston University investigating the role of redox signalling in neovascularisation in type-2 diabetes. He moved back to the UK and was awarded a highly competitive Marie Skłodowska-Curie International Incoming Fellowship to transfer in vivo cardiovascular phenotyping techniques to Aston Medical School working in Prof Asif Ahmed’s laboratory.
Previously he worked as a functional pharmacologist for 5-years with Asterand Bioscience after gaining his honours degree in Pharmacology with Industrial Experience at University of Edinburgh.
Projects
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